Brooke Ann Napier, Phd
Post Doctoral Fellow, Microbiology & Immunology Department, 2014-2017, Stanford University, Stanford, CA
Doctor of Philosophy, Microbiology & Molecular Genetics, 2008-2013, Emory University, Atlanta, GA
Bachelor of Arts, Neuroscience, 2003-2007, Agnes Scott College, Decatur, GA
Assistant Professor of Biology, 12/2017-present
Portland State University, Center for Life in Extreme Environments (CLEE)
Post Doctoral Fellow, 01/2014-11/2017
Stanford University School of Medicine, Advisor: Denise Monack, PhD
Lab Technician, 05/2007 – 07/2008
Emory University School of Medicine and Atlanta Veteran’s Hospital, Advisor: Monica Farley, MD
Research Assistant, 07/2006 – 05/2007
Agnes Scott College, Psychology Department, Advisor: Barbara Blatchley, PhD
National Institute of Health (NIH), National Institute for General Medical Sciences (NIGMS) Maximizing Investigators’ Research Award (MIRA), R35, 2019-2024 ($1,250,000)
Medical Research Foundation New Investigator Grant, 2019-2020 ($40,000)
Collins Medical Trust Grant, 2018-2019 ($30,000)
Faculty Enhancement Award, Portland State University, 2018-2020 ($15,000)
National Institute of Health (NIH) Cooperative Centers for Translational Research in Human Immunology (CCHI) Pilot Project Grant (U19, Mark Davis) at The Stanford Institute for Immunity, Transplantation, and Infection (ITI), 2017-2018 ($40,000)
Katherine McCormick Advanced Post Doctoral Fellowship, Stanford University, 2016-2017 ($8,656)
The Stanford Institute for Immunity, Transplantation, and Infection (ITI) Young Investigator Seed Grant, Stanford Institute for Immunity, Transplantation, & Infection, 2016-2017 ($20,000)
National Institute of Health (NIH), National Institute for Allergies and Infectious Disease (NIAID) Ruth I Kirschstein National Research Services Award (NRSA) Individual Postdoctoral Fellowship (F32), 2015-2018 ($155,110)
Atlanta Research and Education Foundation Fellowship, 2007-2008
Keystone Future of Science Fund Scholarship, Pattern Recognition Signaling: From Innate Immunity to Inflammatory Disease, Keystone Symposia, 2107
Young Investigator Award (Novel Protocol), Nature Publishing Group, 2014
Keystone Global Health Travel Award, Cell Death Signaling in Cancer & the Immune System, Keystone Symposia, 2014
Top 10 Nature Publishing Natural Science Blogs, SmallerQuestions.org, 2011
Teaching Award, Stanford University School of Medicine (nominated by Stanford Medical Students, awarded by: Charles G. Prober, MD, Senior Associate Dean, Medical Education), 2016-2017
Honorable Mention, National Science Foundation (NSF) Graduate Research Fellowship Program, 2009
American Association of Microbiologists (ASM), 2008-present
American Association of Immunologists (AAI), 2014-present
American Association for the Advancement of Science, 2013-present
American Heart Association, 2018-present
Pathogens and Disease, Guest Editor (2015-2017) Thematic Issue Link & Reviewer (2019-present)
PLoS One, Reviewer (2017-present)
Haileselassie B, Mukerjee R, Josh AU, Napier BA, Massis Liliana, Ostberg NP, Monack DM, Berstein D, and Mochly-Rose D (2019). Role of Drp1/Fis1 mediated mitochondrial dysfunction in septic cardiomyopathy. Journal of Molecular and Cellular Cardiology. 2019 Apr 11;130:160-169.
Napier BA, Andres-Terre M*, Massis L*, Hryckowian AJ, Higginbottom SK, Cumnock K, Casey KM, Lugo KA, Schneider DS, Sonnenburg JL, & Monack DM (2019). Western diet regulates immune status and the response to LPS-driven sepsis independent of the diet-associated microbiome. PNAS. 2019 Feb 26;116(9):3688-3694. *, authors contributed equally.
Napier BA and Monack DM (2017) Generating a RAW264.7 CRISPR-Cas9 genome-wide library. Bio Protoc. 2017 May 20;7(10). pii: e2320. doi: 10.21769/BioProtoc.2320.
Napier BA and Monack DM. (2017) Editorial: The sum of all defenses: Tolerance + Resistance. Pathog Dis. Mar 1;75(2). doi: 10.1093/femspd/ftx01.
Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennet ML, Münch AE, Chung WS, Peterson TC, Wilton DK, Frouin A, Napier BA, Panicker N, Kumar M, Buckwalter MS, Rowitch D, Dawson TM, Stevens B, Barres BA. (2017) Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017 Jan 26;541(7638):481-487. doi: 10.1038/nature21029.
Napier BA, Brubaker SW, Sweeney T, Gertsvolf NA, Monnett P, Rothmeier GH, Puschnik A, Carette JE, Khatri P, Monack DM. (2016) Complement pathway enhances caspase-11-dependent cell death and sepsis severity. J Ex Med. 2016. Oct 3. pil. jem.20160027.
Napier BA and Monack DM. (2016). A lipid arsenal to control inflammation. Science. 352(6290):1173-4.
Band VI*, Crispell EK*, Napier BA, Herrera CM, Tharp GK, Vavikolanu K, Pohl J, Read TD, Bosinger SE, Trent MS, Burd EM, Weiss DS. (2016). Antibiotic failure mediated by a resistant subpopulation in Enterobacter cloacae. Nature Microbio. DOI: 10.1038/NMICROBIOL.2016.53. *, authors contributed equally.
Chin CY, Gregg KA, Napier BA, Ernst RK, Weiss DS. (2015) A PmrB-regulated deacetylase required for lipid A modification and polymyxin resistance in Acinetobacter baumannii. Antimicrob Agents Chemother. 00515-15.
Napier RJ, Norris BA, Swimm A, Giver CR, Harris WAC, Laval J, Napier BA, Patel G, Crump R, Peng Z, Bornmann W, Pulendra B, Buller RM, Weiss DS, Tirouvanziam R, Waller EK, Kalman D. (2015) Low doses of Imatinib induce myelopoiesis and enhance host antimicrobial immunity. PLoS Pathogens. 11(3):e1004770.
Napier BA, Band VI, Burd EM*, Weiss DS* (2014). Colistin heteroresistance in Enterobacter cloacae is associated with cross-resistance to host antimicrobial lysozyme. Antimicrob Agents Chemother. 58(9):5594-7. *, co- corresponding authors.
Sampson TR, Napier BA, Schroeder MR, Jones CL, Weiss DS. (2014) Enhancement of envelope integrity by a CRISPR/Cas system promotes evasion of the inflammasome. Proc Natl Acad Sci USA. 111(30):11163-8.
Feng Y, Napier BA, Manandhar M, Henke SK, Weiss DS, Cronan JE. (2014). A Francisella virulence factor catalyzes an essential reaction of biotin biosynthesis. Mol Microbiol. 91(2):300-14.
Napier BA, Burd EM, Satola SW, Cagle SM, Ray SM, McGann P, Pohl J, Lesho EP, Weiss DS. (2013). Clinical use of colistin induces cross-resistance to host antimicrobials in Acinetobacter baumannii. mBio. 4(3):e00021-13. *Recommended by Faculty of 1000
Napier BA, Meyer L, Bina JE, Miller MA, Sjöstedt A, Weiss DS. (2012). A link between biotin and rapid phagosomal escape in Francisella. Proc Natl Acad Sci USA. 109(44):1804-89.
Jones CL*, Napier BA*, Sampson TR*, Llewllyn AC, Schroeder MR, Weiss DS. (2012). Subversion of host recognition and defense systems by Francisella spp. Microbiol Mol Biol Rev. 76(2): 383-404. *Authors contributed equally to this manuscript
Llewellyn AC, Zhao J, Song F, Parvathareddy J, Xu Q, Napier BA, Laroui H, Merlin D, Bina JE, Cotter PA, Miller MA, Raetz CR, Weiss DS. (2012). NaxD is a deacetylase required for lipid A modification and Francisella pathogenesis. Mol Microbiol. 86(3):611-27.
Llewellyn AC, Jones CL*, Napier BA*, Bina JE, Weiss DS. (2011). Macrophage replication screen identifies a novel Francisella hydroperoxide resistance protein involved in virulence. PloS ONE. 6(9): e24201. *All contributed equally to this manuscript.
Limbago B, Fosheim GE, Schoonover V, Crane CE, Nadle J, Petit S, Heltzel D, Ray SM, Harrison LH, Lynfield R, Dumyati G, Townes JM, Schaffner W, Mu Y, Fridkin SK; Active Bacterial Core surveillance MRSA Investigators. Characterization of methicillin-resistant Staphylococcus aureus isolates collected in 2005 and 2006 from patients with invasive disease: a population-based analysis. J Clin Microbiol. 2009 May;47(5):1344-51.
Satola SW, Napier BA, Farley MM. (2008). Association of IS1016 with the hia adhesion gene and biotypes V and I in invasive nontypeable Haemophilus influenzae. Infect Immun. 76(11):5221-7.
Napier BA (2012). Changing the Learning Landscape. Agnes Scott Magazine (Fall).
Microbiology & Nutrition Departments, Oregon State University, 2019.
ASM Northwest Branch Meeting, Oregon Health & Science University, 2018.
Pulmonary & Critical Care Medicine (PCCM), Oregon Health & Science University, 2018.
Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, 2018.
Carter Immunology Center Seminar, University of Virginia. Charlottesville, VA. 2016.
Symposium on Synthetic Immunity, New Mexico Consortium. Santa Fe, NM. 2017.
XL Congress of the Brazilian Society of Immunology. Guaruja, São Paulo, Brazil. 2015.
9th Annual DSAC Student Research Symposium, Emory University, Atlanta, GA. 2011.
Dr BrainLove, LLC. San Francisco, CA. 94110. 2016.
Karius, LLC. Menlo Park, CA, 94025. 2016.
TechTalk, Highgroove Studios. Atlanta, Georgia. 2012.
Cold Spring Harbor Laboratory Microbial Pathogenesis and Host Response. Cold Spring Harbor, NY. 2019.
Immunometabolism, Metaflammation, and Metabolic Disorders, Keystone Symposia. Vancouver, British Columbia, CA. 2019.
Pattern Recognition Signaling: From Innate Immunity to Inflammatory Disease, Keystone Symposia. Banff, Alberta, CA. 2017.
Gordon Research Conference: Microbial Toxins and Pathogenicity. Waterville Valley, NH. 2016.
Cell Symposia: Cell Death and Immunity. Berkeley, CA. 2015.
Cell Death Signaling in Cancer and the Immune System, Keystone Symposium. Guaruja, São Paulo, Brazil. 2014. Awarded most Novel Method from Nature Protocols.
Gordon Research Conference Microbial Toxins and Pathogenicity. Waterville Valley, NH. 2012.
Cold Spring Harbor Laboratory Microbial Pathogenesis & Host Response. Cold Spring Harbor, NY. 2011.
Proceedings of the American Society for Microbiology, General Meeting, Boston, MA. 2008.