Brooke Ann Napier, Phd

 

Education

Doctor of Philosophy, Microbiology & Molecular Genetics, 2008-2013, Emory University, Atlanta, GA

Bachelor of Arts, Neuroscience, 2003-2007, Agnes Scott College, Decatur, GA 

 

positions

Assistant Professor of Biology, 12/2017-present
Portland State University, Center for Life in Extreme Environments (CLEE)

Post Doctoral Fellow, 01/2014-11/2017
Stanford University School of Medicine, Advisor: Denise Monack, PhD

Graduate Student, 07/2008 – 12/2013, Dissertation 
Emory University School of Medicine and The Emory Vaccine Center, Advisor: David Weiss, PhD

Lab Technician, 05/2007 – 07/2008
Emory University School of Medicine and Atlanta Veteran’s Hospital, Advisor: Monica Farley, MD

Research Assistant, 07/2006 – 05/2007
Agnes Scott College, Psychology Department, Advisor: Barbara Blatchley, PhD

 

Grants

Faculty Enhancement Award, Portland State University, 2018-2020 ($15,000)

National Institute of Health (NIH) Cooperative Centers for Translational Research in Human Immunology (CCHI) Pilot Project Grant (U19, Mark Davis) at The Stanford Institute for Immunity, Transplantation, and Infection (ITI), 2017-2018 ($40,000)

Katherine McCormick Advanced Post Doctoral Fellowship, Stanford University, 2016-2017 ($8656)

The Stanford Institute for Immunity, Transplantation, and Infection (ITI) Young Investigator Seed Grant, Stanford Institute for Immunity, Transplantation, & Infection, 2016-2017 ($20,000)

National Institute of Health (NIH), National Institution for Allergies and Infectious Disease (NIAID) Ruth I Kirschstein National Research Services Award (NRSA) Individual Postdoctoral Fellowship (F32), 2015-2018 ($155,110)

Atlanta Research and Education Foundation Fellowship, 2007-2008

 

AWARDS

Keystone Future of Science Fund Scholarship, Pattern Recognition Signaling: From Innate Immunity to Inflammatory Disease, Keystone Symposia, 2107

Young Investigator Award (Novel Protocol), Nature Publishing Group, 2014

Keystone Global Health Travel Award, Cell Death Signaling in Cancer & the Immune System, Keystone Symposia, 2014

Top 10 Nature Publishing Natural Science Blogs, SmallerQuestions.org, 2011

 

Honors

Teaching Award, Stanford University School of Medicine (nominated by Stanford Medical Students, awarded by: Charles G. Prober, MD, Senior Associate Dean, Medical Education), 2016-2017

Honorable Mention, National Science Foundation (NSF) Graduate Research Fellowship Program, 2009

Dean’s Honor List, Agnes Scott College, 2007

 

service & outreach

Judge, Stanford Summer Research Program (SSRP) Symposium, 2016

Co-Coordinator, Stanford Microbiology & Immunology Postdoc Town Hall Meetings, 2015-present

Post-doc representative, Stanford Microbiology & Immunology Noon Seminar Series, 2015-2016

Co-creator/Co-author, Smaller Questions Science Blog (www.SmallerQuestions.org), 2011-2013

Co-president, Emory University  Microbiology & Molecular Genetics Student Symposium, 2008-2012

Judge, Emory University Undergraduate Fall/Spring Research Symposium, 2010-2013

Judge, Georgia Science and Engineering Fair – Classic Center, Athens, GA, 2011-2012 Judge/Career Panel

Dekalb Science and Engineering Fair (Senior Division), 2011

Biologist Chair, Agnes Scott Women in Science Career Panel, 2010 

 

 

scientific organizations

American Association of Immunologists (AAI), 2014-present 

American Association for the Advancement of Science, 2013-present 

 

Academic service

Pathogens and Disease, Guest Editor (2015-2017) Thematic Issue Link

PLoS One, Reviewer (2017-present)

 

publications

Napier BA and Monack DM (2017) Generating a RAW264.7 CRISPR-Cas9 genome-wide library. Bio Protoc. 2017 May 20;7(10). pii: e2320. doi: 10.21769/BioProtoc.2320.

Napier BA and Monack DM. (2017) Editorial: The sum of all defenses: Tolerance + Resistance. Pathog Dis. Mar 1;75(2). doi: 10.1093/femspd/ftx01.

Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennet ML, Münch AE, Chung WS,  Peterson TC, Wilton DK, Frouin A, Napier BA, Panicker N, Kumar M, Buckwalter MS, Rowitch D, Dawson TM, Stevens B, Barres BA. (2017) Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017 Jan 26;541(7638):481-487. doi: 10.1038/nature21029.

Napier BA, Brubaker SW, Sweeney T, Gertsvolf NA, Monnett P, Rothmeier GH, Puschnik A, Carette JE, Khatri P, Monack DM. (2016) Complement pathway enhances caspase-11-dependent cell death and sepsis severity. J Ex Med. 2016. Oct 3. pil. jem.20160027.

Napier BA and Monack DM. (2016). A lipid arsenal to control inflammation. Science. 352(6290):1173-4.

Band VI*, Crispell EK*, Napier BA, Herrera CM, Tharp GK, Vavikolanu K, Pohl J, Read TD, Bosinger SE, Trent MS, Burd EM, Weiss DS. (2016). Antibiotic failure mediated by a resistant subpopulation in Enterobacter cloacae. Nature Microbio. DOI: 10.1038/NMICROBIOL.2016.53. *, authors contributed equally.

Chin CY, Gregg KA, Napier BA, Ernst RK, Weiss DS. (2015) A PmrB-regulated deacetylase required for lipid A modification and polymyxin resistance in Acinetobacter baumannii. Antimicrob Agents Chemother. 00515-15.

Napier RJ, Norris BA, Swimm A, Giver CR, Harris WAC, Laval J, Napier BA, Patel G, Crump R, Peng Z, Bornmann W, Pulendra B, Buller RM, Weiss DS, Tirouvanziam R, Waller EK, Kalman D. (2015) Low doses of Imatinib induce myelopoiesis and enhance host antimicrobial immunity. PLoS Pathogens. 11(3):e1004770.

Napier BA, Band VI, Burd EM*, Weiss DS* (2014). Colistin heteroresistance in Enterobacter cloacae is associated with cross-resistance to host antimicrobial lysozyme. Antimicrob Agents Chemother. 58(9):5594-7. *, co- corresponding authors.

Sampson TR, Napier BA, Schroeder MR, Jones CL, Weiss DS. (2014) Enhancement of envelope integrity by a CRISPR/Cas system promotes evasion of the inflammasome. Proc Natl Acad Sci USA. 111(30):11163-8.

Feng Y, Napier BA, Manandhar M, Henke SK, Weiss DS, Cronan JE. (2014). A Francisella virulence factor catalyzes an essential reaction of biotin biosynthesis. Mol Microbiol. 91(2):300-14.

Napier BA, Burd EM, Satola SW, Cagle SM, Ray SM, McGann P, Pohl J, Lesho EP, Weiss DS. (2013). Clinical use of colistin induces cross-resistance to host antimicrobials in Acinetobacter baumannii. mBio. 4(3):e00021-13. *Recommended by Faculty of 1000

Napier BA, Meyer L, Bina JE, Miller MA, Sjöstedt A, Weiss DS. (2012). A link between biotin and rapid phagosomal escape in Francisella. Proc Natl Acad Sci USA. 109(44):1804-89.

Jones CL*, Napier BA*, Sampson TR*, Llewllyn AC, Schroeder MR, Weiss DS. (2012). Subversion of host recognition and defense systems by Francisella spp. Microbiol Mol Biol Rev. 76(2): 383-404. *Authors contributed equally to this manuscript

Llewellyn AC, Zhao J, Song F, Parvathareddy J, Xu Q, Napier BA, Laroui H, Merlin D, Bina JE, Cotter PA, Miller MA, Raetz CR, Weiss DS. (2012). NaxD is a deacetylase required for lipid A modification and Francisella pathogenesis. Mol Microbiol. 86(3):611-27.

Llewellyn AC, Jones CL*, Napier BA*, Bina JE, Weiss DS. (2011). Macrophage replication screen identifies a novel Francisella hydroperoxide resistance protein involved in virulence. PloS ONE. 6(9): e24201. *All contributed equally to this manuscript.

Limbago B, Fosheim GE, Schoonover V, Crane CE, Nadle J, Petit S, Heltzel D, Ray SM, Harrison LH, Lynfield R, Dumyati G, Townes JM, Schaffner W, Mu Y, Fridkin SK; Active Bacterial Core surveillance MRSA Investigators. Characterization of methicillin-resistant Staphylococcus aureus isolates collected in 2005 and 2006 from patients with invasive disease: a population-based analysis. J Clin Microbiol. 2009 May;47(5):1344-51.

Satola SW, Napier BA, Farley MM. (2008). Association of IS1016 with the hia adhesion gene and biotypes V and I in invasive nontypeable Haemophilus influenzae. Infect Immun. 76(11):5221-7.

Non-academic publication

Napier BA (2012). Changing the Learning Landscape. Agnes Scott Magazine (Fall). 

 

Invited talks

Seminar Series

Pulmonary & Critical Care Medicine (PCCM), Oregon Health and Science University, 2018.

Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, 2018.

Carter Immunology Center Seminar, University of Virginia. Charlottesville, VA. 2016.

Conferences

Symposium on Synthetic Immunity, New Mexico Consortium. Santa Fe, NM. 2017.

XL Congress of the Brazilian Society of Immunology. Guaruja, São Paulo, Brazil. 2015.

9th Annual DSAC Student Research Symposium, Emory University, Atlanta, GA. 2011.

Industry Talks

Dr BrainLove, LLC. San Francisco, CA. 94110. 2016.

Karius, LLC. Menlo Park, CA, 94025. 2016.

TechTalk, Highgroove Studios. Atlanta, Georgia. 2012.

 

Posters

Pattern Recognition Signaling: From Innate Immunity to Inflammatory Disease Keystone Symposia. Banff, Alberta, CA. 2017.

Gordon Research Conference: Microbial Toxins and Pathogenicity. Waterville Valley, NH. 2016.

Cell Symposia: Cell Death and Immunity. Berkeley, CA. 2015.

Cell Death Signaling in Cancer and the Immune System Keystone Symposium. Guaruja, São Paulo, Brazil. 2014. Awarded most Novel Method from Nature Protocols. 

Gorden Research Conference Microbial Toxins and Pathogenicity. Waterville Valley, NH. 2012.

Cold Spring Harbor Laboratory Microbial Pathogenesis & Host Response. Cold Spring Harbor, NY. 2011.

Proceedings of the American Society for Microbiology, General Meeting, Boston, MA. 2008.